Hallucinations and delusions are two telltale signs of schizophrenia. According to research or other evidence, the following self-care steps may be helpful in managing this serious mental disorder:
What you need to know
- Go for the glycine
- With a healthcare professional’s supervision, help improve symptoms such as depression with daily use of this nutritional supplement; take 0.8 grams for every 2.2 pounds (1 kg) of body weight
- Rest easy with melatonin
- Improve sleep quality and duration with this natural hormone; take 2 mg of a controlled-release preparation before bedtime
- Try megadose vitamin therapy
- Work with a healthcare professional knowledgeable in nutritional treatment of schizophrenia to find out whether large amounts of vitamin B3, B6, or C improves symptoms
- Find a fix for low folic acid levels
- Visit your healthcare provider to determine if your blood is low in folic acid, and if 10 to 20 mg a day of this vitamin might help improve symptoms
- Uncover food sensitivities
- Work with a nutritionist to follow a gluten-free, dairy-free diet that may help improve responses to medication
These recommendations are not comprehensive and are not intended to replace the advice of your doctor or pharmacist. Continue reading the full schizophrenia article for more in-depth, fully-referenced information on medicines, vitamins, herbs, and dietary and lifestyle changes that may be helpful.
About schizophrenia
Schizophrenia is a common and serious mental disorder characterized by loss of contact with reality.
The behaviors, described below, must be present for six months or longer to establish a diagnosis. Approximately 1% of the world’s population is affected by this condition. Schizophrenia is more common among lower socioeconomic classes in urban areas, perhaps because its disabling effects lead to unemployment and poverty. In the United States, 25% of all hospital beds are occupied by people with schizophrenia.
Product ratings for schizophrenia
| Science Rating | Nutritional Supplements | Herbs |
|---|---|---|
 | Folic acid (if deficient) Glycine | |
 | Melatonin (for sleep disturbances only) Niacin/niacinamide (vitamin B3) Omega-3 fatty acids (fish oil) Vitamin B6 Vitamin C | Ginkgo biloba (in combination with haloperidol) |
 | D-Serine Vitamin B12 | |
| Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit. | ||
What are the symptoms?
Symptoms and signs of schizophrenia include loss of contact with reality (psychosis), auditory and visual hallucinations (false perceptions), delusions (false beliefs), abnormal thinking, restricted range of emotions, diminished motivation, and disturbed work and social functioning. People with schizophrenia may also engage in speech that does not make sense, exhibit silly or childlike facial expressions, and experience poor memory or confusion.
Medical options
Antipsychotic medications, also known as major tranquilizers, are used to treat schizophrenia. Commonly prescribed drugs include olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), ziprasidone (Geodon), aripiprazole (Abilify), mesoridazine (Serentil), molindone (Moban), and clozapine (Clozaril). Older agents, such as haloperidol (Haldol), chlorpromazine (Thorazine), andfluphenazine (Prolixin), are also prescribed. Other medications might be prescribed to control depression, anxiety, or hostility in schizophrenic individuals.
Psychological counseling or electroconvulsive therapy (electrical current applied to the brain) may also be recommended.
Dietary changes that may be helpful
For many years there has been speculation that certain dietary proteins may contribute to the symptoms of schizophrenia.1 2 3 Gluten, a protein from wheat and some other grains, and to a lesser extent casein, a dairy protein, have been the targets of research on food sensitivities as contributors to schizophrenia.4 People with schizophrenia have been shown to be more likely to have immune reactions to these proteins, than the general population.5 A preliminary trial of a gluten-free/dairy-free diet found that patients with schizophrenia improved on the diet and had shorter hospital stays than those eating normal diets.6 The results of double-blind trials, however, have been inconsistent. The gluten-free/dairy-free diet improved responses to medications in one controlled trial.7 These improvements were lost and symptoms of schizophrenia were aggravated when gluten was re-introduced in a “blinded” fashion. Another clinical trial found similar positive responses in only 8% of patients.8 Other controlled trials have found no improvement when gluten and dairy were removed from the diet.9 10 In one clinical trial, blinded reintroduction of gluten appeared to cause improvement of symptoms.11 These results suggest that some, but not all, people with schizophrenia may benefit from a gluten-free/dairy-free diet.
Lifestyle changes that may be helpful
Exercise has long been recognized for its benefits in treating mild to moderate depression and there is some evidence that it may also be helpful in reducing anxiety.12 In one reported case, physical activity improved the functioning of a man diagnosed with schizophrenia.13 In another reported case, aggressive outbursts in a schizophrenic patient were reduced after he began exercising.14 A preliminary trial of an exercise program for hospitalized psychiatric patients with varying diagnoses resulted in significantly reduced symptoms of depression and an insignificant trend towards reduced anxiety.15 Additional research is needed to determine the specific benefits of exercise in people with schizophrenia.
Vitamins that may be helpful
People with schizophrenia may have a greater tendency to be deficient in folic acid, than the general population16 and they may show improvement when given supplements. A preliminary trial found that, among schizophrenic patients with folic acid deficiency, those given folic acid supplements had more improvement, and shorter hospital stays than those not given supplements.17 In a double-blind trial, a very high amount of folic acid (15 mg daily) was given to schizophrenic patients being treated with psychiatric medications who had low or borderline folic acid levels. The patients receiving the folic acid supplements had significant improvement, which became more significant over the six-month course of the trial.18 The symptoms of folic acid deficiency can be similar to those of schizophrenia, and two cases of wrong “schizophrenia” diagnoses have been reported.19 20 In one of these cases, an initial supplement of 20 mg daily of folic acid and a maintenance supplemental intake of 10 mg daily, led to resolution of symptoms.21
There have been several reports of glycine reducing the symptoms of people with schizophrenia who were unresponsive to drug therapy.22 Large amounts of glycine (0.8 gram per 2.2 pounds of body weight per day) have been shown to reduce negative symptoms of schizophrenia and improve psychiatric rating scores in one preliminary trial;23 however, these results have not been repeated in later trials using similar (very high) amounts.24 25 Earlier double-blind trials found significant improvements in depression and mental symptoms in people with schizophrenia who took glycine for six weeks.26 27 Most trials demonstrated a moderate improvement in schizophrenia symptoms in those taking glycine supplements.28 Long-term supplementation with high amounts of glycine may be toxic to nerve tissue, however. Some preliminary successes have been reported using smaller amounts of glycine, such as 10 grams per day.29 Long-term studies on the safety of glycine therapy are needed.
The term “orthomolecular psychiatry” was coined by Linus Pauling in 1968 to refer to the treatment of psychiatric illnesses with substances (such as vitamins) that are normally present in the body. In orthomolecular psychiatry, high amounts of vitamins are sometimes used, not to correct a deficiency per se, but to create a more optimal biochemical environment. The mainstay of the orthomolecular approach to schizophrenia is niacin or niacinamide (vitamin B3) in high amounts. In early double-blind trials, 3 grams of niacin daily resulted in a doubling of the recovery rate, a 50% reduction in hospitalization rates, and a dramatic reduction in suicide rates.30 In a preliminary trial, some schizophrenic patients continued a course of vitamins (4 to 10 grams of niacin or niacinamide, 4 grams of vitamin C, and 50 mg or more of vitamin B6) after being discharged from the hospital, while another group of patients discontinued the vitamins upon discharge. Both groups continued to take their psychiatric medications. Those who continued to take the vitamins had a 50% lower re-admission rate compared with those who did not.31 Several later double-blind trials, including trials undertaken by the Canadian Mental Health Association, have been unable to reproduce these positive results.32 33 Early supporters of niacin therapy contend that many of these trials were poorly designed.34 One clinical trial reported no greater improvement in a group of schizophrenic patients given 6 grams of niacin than in others given 3 mg of niacin; all patients were also being treated with psychiatric medications.35
There are potential side-effects of niacin therapy, including an uncomfortable flushing sensation, dermatitis (skin inflammation), heartburn, aggravation of peptic ulcers, increased blood sugar, increased panic and anxiety, and elevation of liver enzymes, which may indicate damage to liver cells. A positive side effect of niacin therapy is reduction of cholesterol levels. Some of these effects, such as flushing, gastric upset, and reduction of serum cholesterol, do not occur with the use of niacinamide.36 Because of the seriousness of some of these side effects, high amounts of niacin should not be used without the supervision of a healthcare practitioner.
Vitamin B6 has been used in combination with niacin in the orthomolecular approach to schizophrenia. Pioneers of orthomolecular medicine reported benefits from this combination. However, although two placebo-controlled trials found significant improvement when schizophrenic patients were given either 3 grams of niacin or 75 mg of pyridoxine along with their psychiatric medications, this improvement was lost when the two vitamins were combined.37 38 In a double-blind trial, schizophrenic patients were given either a vitamin program based on their individual laboratory tests or a placebo (25 mg of vitamin C) in addition to their psychiatric medications. The vitamin program included large amounts of various B vitamins, as well as vitamin C and vitamin E. After five months, the number of patients who improved was not different in the vitamin group compared with the placebo group.39
Clinical trials of the effects of vitamin B6 have yielded differing results. The results of supplementation with 100 mg daily in one schizophrenic patient included dramatic reduction in side effects from medication, as well as reduction in schizophrenic symptoms.40 In a preliminary trial, 60 mg per day of vitamin B6 resulted in symptomatic improvement in only 5% of schizophrenic patients after four weeks.41 Another preliminary trial, however, found that a higher amount of vitamin B6—50 mg three times daily given for eight to twelve weeks—in addition to psychiatric medications, did bring about significant improvements in schizophrenic patients. These patients experienced a better sense of well-being, increased motivation, and greater interest in their “personal habits and their environment.”42
Up to 6 grams daily of vitamin C has been reported to be beneficial for people with schizophrenia;43 44 in one case the addition of 400 IU daily of vitamin E enhanced this benefit.45 A small preliminary trial using 8 grams daily of vitamin C showed decreases in hallucinations, suspiciousness, and unusual and disorganized thoughts in 77% of schizophrenic patients.46 In all reported cases, patients were also being treated with sychiatric medications. Some early studies found no difference between blood and urine vitamin C levels in schizophrenics and non-schizophrenics, either before or after supplementation.47 48 49 However, later studies found that blood and urine levels of vitamin C were lower in schizophrenics than in non-schizophrenics before and after a single 1,000 mg “load” of vitamin C was taken. After four weeks of daily supplementation with 1,000 mg of vitamin C, blood levels became the same, but urinary levels remained lower in the schizophrenic group, leading the researchers to conclude that the amount of vitamin C required by people with schizophrenia may be greater than that of the general population.50 51
There are two different classes of essential fatty acids: omega-6 fatty acids and omega-3 fatty acids. There is considerable evidence these fatty acids are deficient, or are not used properly, in people with schizophrenia.52 53 54 55 56 57 Some investigators suggest this altered fatty acid metabolism may be involved in the increased need for niacin seen in some schizophrenic patients.58 A case has been reported in which a man with schizophrenia had dramatic and sustained improvement while being supplemented with 2 grams daily of omega-3 fatty acids.59 In a preliminary trial, schizophrenic patients receiving omega-3 fatty acids showed improvement in symptoms, as well as a reduction in adverse effects from their anti-psychotic medications.60 Another study found that people with schizophrenia had lower blood levels of both omega-3 and omega-6 fatty acids, compared with non-schizophrenic people, even though both groups were consuming similar amounts of these fatty acids.61 In a separate preliminary study, higher intake of omega-3 fatty acids was associated with less severe disease, and supplementation with 10 grams of concentrated fish oil, a source of omega-3 fatty acids, led to significant improvement in symptoms over a six-week period.62
However, in a double-blind trial that included 87 patients with chronic schizophrenia or a related illness (schizoaffective disorder), supplementation with 3 grams per day of eicosapentaenoic acid (one of the omega-3 fatty acids found in fish oil) was ineffective.63 The patients in this negative study were older and had been ill for longer, compared with patients in earlier studies who improved with omega-3 fatty acid supplementation.
Several clinical trials have examined the effects of supplementation with essential fatty acids in people with schizophrenia, with inconsistent results.64 65 66 67 While the results of trials using omega-3 fatty acids are promising, further double-blind trials are needed to establish whether fatty acid supplementation is an effective therapy for schizophrenia. Trials of omega-6 fatty acids (like GLA from borage oil) have yielded predominantly negative results.68
The results of one double-blind trial indicate that melatonin supplementation improves sleep quality in people with schizophrenia.69 In one study, all patients with a diagnosis of schizophrenia were found to have low melatonin output. Replacement of melatonin with 2 mg of a controlled-release supplement per day for three weeks improved sleep duration and quality compared to placebo. When patients receiving placebo were crossed over to the melatonin group, they too experienced improved sleep quality.
L-tryptophan is the amino acid precursor of serotonin, a neurotransmitter (chemical messenger in the brain). There is evidence that L-tryptophan levels in schizophrenic people are lower than in non-schizophrenics70 and the way the body uses L-tryptophan is altered in people with schizophrenia.71 72 In a preliminary trial, patients with schizophrenia were given 2–8 grams of L-tryptophan and 100 mg of vitamin B6 daily. This resulted in decreased agitation and less fear and anxiety, but these improvements were not as great as those achieved with psychiatric medications.73 It is not clear whether the benefits seen in this trial were due to vitamin B6, L-tryptophan, or a combination of the two. No other clinical trials using L-tryptophan have been published. L-tryptophan is currently available by prescription only.
Vitamin B12 deficiency can cause symptoms that are similar to those of schizophrenia and one case has been reported in which such symptoms cleared after supplementation with vitamin B12.74 Some studies have reported finding lower levels of vitamin B12 in people with schizophrenia than in the general population,75 but others have found no difference.76 No trials of vitamin B12 supplementation in schizophrenic patients have been published.
Supplementation with the amino acid, D-serine, may improve mental symptoms in people with schizophrenia who are also taking antipsychotic medications. In a double-blind trial, D-serine or placebo was dissolved in orange juice and taken daily for six weeks by people with schizophrenia who were also taking antipsychotic medications.77 The amount of D-serine used was 30 mg per 2.2 pounds of body weight per day. Those taking the D-serine experienced significant improvements in mental functioning and symptoms related to schizophrenia. Further trials are needed to determine if these effects can be produced in the absence of concurrent antipsychotic medications.
Are there any side effects or interactions?
Refer to the individual supplement for information about any side effects or interactions.
Herbs that may be helpful
In a double-blind trial, supplementation of schizophrenic patients with Ginkgo biloba extract, in the amount of 250 mg per 2.2 pounds of body weight per day for 12 weeks, enhanced the effectiveness of the antipsychotic drug haloperidol (Haldol®) and also reduced the side effects of the drug.78
Are there any side effects or interactions?
Refer to the individual herb for information about any side effects or interactions.
Holistic approaches that may be helpful
Magnetic stimulation to the skull and underlying motor cortex (the part of the brain that controls movement) significantly reduced auditory hallucinations in a group of people with schizophrenia in a small, controlled trial.79 The procedure was performed by psychiatrists using sophisticated electromagnetic medical equipment, not a simple magnet.
References
1. Hall K. Allergy of the nervous system: a review. Ann Allergy 1976;36:49–64 [review].
2. Kety SS. Editorial: Dietary factors and schizophrenia. Ann Intern Med 1976;84:745 [editorial].
3. Ross-Smith P, Jenner FA. Diet (gluten) and schizophrenia. J Hum Nutr 1980;34:107–12 [review].
4. Dohan FC. Genetic hypothesis of idiopathic schizophrenia: its exorphin connection. Schizophr Bull 1988;14:489–94.
5. Reichelt KL, Landmark J. Specific IgA antibody increases in schizophrenia. Biol Psychiatry 1995;37:410–3.
6. Dohan FC, Grasberger JC. Relapsed schizophrenics: earlier discharge from the hospital after cereal-free, milk-free diet. Am J Psychiatry 1973;130:685–8.
7. Singh MM, Kay SR. Wheat gluten as a pathogenic factor in schizophrenia. Science 1976;191:401–2.
8. Vlissides DN, Venulet A, Jenner FA. A double-blind gluten-free/gluten-load controlled trial in a secure ward population. Br J Psychiatry 1986;148:447–52.
9. Davis C. Dietary pathogenesis of schizophrenia: an investigation into the effects of gluten. Nurs Times 1978;74:2020–1.
10. Potkin SG, Weinberger D, Kleinman J, et al. Wheat gluten challenge in schizophrenic patients. Am J Psychiatry 1981;138:1208–11.
11. Storms LH, Clopton JM, Wright C. Effects of gluten on schizophrenics. Arch Gen Psychiatry 1982;39:323–7.
12. Taylor CB, Sallis JF, Needle R. The relation of physical activity and exercise to mental health. Public Health Rep 1985;100:195–202 [review].
13. Adams L. How exercise can help people with mental health problems. Nurs Times 1995;91:37–9.
14. Belcher TL. Behavioral reduction of overt hallucinatory behavior in a chronic schizophrenic. J Behav Ther Exp Psychiatry 1988;19:69–71.
15. Conroy RW, Smith K, Felthous AR. The value of exercise on a psychiatric hospital unit. Hosp Community Psychiatry 1982;33:641–5.
16. Herran A, Garcia-Unzueta MT, Amado JA, et al. Folate levels in psychiatric outpatients. Psychiatry Clin Neurosci 1999;53:531–3.
17. Carney MW, Sheffield BF. Associations of subnormal serum folate and vitamin B12 values and effects of replacement therapy. J Nerv Ment Dis 1970;150:404–12.
18. Procter A. Enhancement of recovery from psychiatric illness by methylfolate. Br J Psychiatry 1991;159:271–2.
19. Freeman JM, Finkelstein JD, Mudd SH. Folate-responsive homocystinuria and “schizophrenia.” A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. N Engl J Med 1975;292:491–6.
20. Folate-responsive homocystinuria and “schizophrenia.”Nutr Rev 1982;40:242–5.
21. Folate-responsive homocystinuria and “schizophrenia.”Nutr Rev 1982;40:242–5.
22. Waziri R. Glycine therapy of schizophrenia: Some caveats. Biol Psychiatry 1996;39:155–6.
23. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29–36.
24. Evins AE, Fitzgerald SM, Wine L, et al. Placebo-controlled trial of glycine added to clozapine in schizophrenia. Am J Psychiatry 2000;157:826–8.
25. Potkin SG, Jin Y, Bunney BG, et al. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145–7.
26. Heresco-Levy U, Javitt DC, Ermilov M, et al. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry 1996;169:610–7.
27. Javitt DC, Zylberman I, Zukin SR, et al. Amelioration of negative symptoms in schizophrenia by glycine. Am J Psychiatry 1994;151:1234–6.
28. Semba J. [Glycine therapy of schizophrenia; its rationale and a review of clinical trials]. Nihon Shinkei Seishin Yakurigaku Zasshi 1998;18:71–80 [review] [in Japanese].
29. Rosse RB, Theut SK, Banay-Schwartz M, et al. Glycine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label, pilot study. Clin Neuropharmacol 1989;12:416–24.
30. Hawkins DR, Bortin AW, Runyon RP. Orthomolecular psychiatry: niacin and megavitamin therapy. Psychosomatics 1970;11:517–21 [review].
31. Hawkins DR, Bortin AW, Runyon RP. Orthomolecular psychiatry: niacin and megavitamin therapy. Psychosomatics 1970;11:517–21 [review].
32. Autry JH. Workshop on orthomolecular treatment of schizophrenia: a report. Schizophr Bull 1975:94–103.
33. Petrie WM, Ban TA. Vitamins in psychiatry. Do they have a role? Drugs 1985;30:58–65 [review].
34. Hoffer A. Megavitamin B-3 therapy for schizophrenia. Can Psychiatr Assoc J 1971;16:499–504.
35. Wittenborn JR, Weber ES, Brown M. Niacin in the long-term treatment of schizophrenia. Arch Gen Psychiatry 1973;28:308–15.
36. Newbold HL, Mosher LR. Niacin and the schizophrenic patient. Am J Psychiatry 1970;127:535–6.
37. Petrie WM, Ban TA, Ananth JV. The use of nicotinic acid and pyridoxine in the treatment of schizophrenia. Int Pharmacopsychiatry 1981;16:245–50.
38. Ananth JV, Ban TA, Lehmann HE. Potentiation of therapeutic effects of nicotinic acid by pyridoxine in chronic schizophrenics. Can Psychiatr Assoc J 1973;18:377–83.
39. Vaughan K, McConaghy N. Megavitamin and dietary treatment in schizophrenia: a randomised, controlled trial. Aust N Z J Psychiatry 1999;33:84–8.
40. Sandyk R, Pardeshi R. Pyridoxine improves drug-induced parkinsonism and psychosis in a schizophrenic patient. Int J Neurosci 1990;52:225–32.
41. Yamauchi M. Effects of L-dopa and vitamin B6 on electroencephalograms of schizophrenic patients: a preliminary report. Folia Psychiatr Neurol Jpn 1976;30:121–51.
42. Bucci L. Pyridoxine and schizophrenia. Br J Psychiatry 1973;122:240 [letter].
43. Sandyk R, Kanofsky JD. Vitamin C in the treatment of schizophrenia. Int J Neurosci 1993;68:67–71.
44. Kanofsky JD, Sandyk R. Antioxidants in the treatment of schizophrenia. Int J Neurosci 1992;62:97–100 [letter].
45. Kanofsky JD, Sandyk R. Antioxidants in the treatment of schizophrenia. Int J Neurosci 1992;62:97–100 [letter].
46. Beauclair L, Vinogradov S, Riney SJ, et al. An adjunctive role for ascorbic acid in the treatment of schizophrenia? J Clin Psychopharmacol 1987;7:282–3 [letter].
47. Pitt B, Pollitt N. Ascorbic acid and chronic schizophrenia. Br J Psychiatry 1971;118:227–8.
48. Grant FW, Cowen MA, Ozerengin MF, Bigelow N. Nutritional requirements in mental illness. I. Ascorbic acid retention in schizophrenia. A reexamination. Biol Psychiatry 1973;5:289–94.
49. Pitt B. Vitamin C and schizophrenia. Lancet 1974;2:1153–4 [letter].
50. Suboticanec K, Folnegovic-Smalc V, Turcin R, et al. Plasma levels and urinary vitamin C excretion in schizophrenic patients. Hum Nutr Clin Nutr 1986;40:421–8.
51. Suboticanec K, Folnegovic-Smalc V, Korbar M, et al. Vitamin C status in chronic schizophrenia. Biol Psychiatry 1990;28:959–66.
52. Horrobin DF. The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism. Prostaglandins Leukot Essent Fatty Acids 1992;46:71–7 [review].
53. Horrobin DF. Schizophrenia as a membrane lipid disorder which is expressed throughout the body. Prostaglandins Leukot Essent Fatty Acids 1996;55:3–7 [review].
54. Warner R, Laugharne J, Peet M, et al. Retinal function as a marker for cell membrane omega-3 fatty acid depletion in schizophrenia: a pilot study. Biol Psychiatry 1999;45:1138–42.
55. Mahadik SP, Mukherjee S, Horrobin DF, et al. Plasma membrane phospholipid fatty acid composition of cultured skin fibroblasts from schizophrenic patients: comparison with bipolar patients and normal subjects. Psychiatry Res 1996;63:133–42.
56. Vaddadi KS, Gilleard CJ, Soosai E, et al. Schizophrenia, tardive dyskinesia and essential fatty acids. Schizophr Res 1996;20:287–94.
57. Peet M, Laugharne J, Rangarajan N, et al. Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients. J Psychiatr Res 1995;29:227–32.
58. Rudin DO. The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra. Biol Psychiatry 1981;16:837–50.
59. Puri BK, Richardson AJ, Horrobin DF, et al. Eicosapentaenoic acid treatment in schizophrenia associated with symptom remission, normalisation of blood fatty acids, reduced neuronal membrane phospholipid turnover and structural brain changes. Int J Clin Pract 2000;54:57–63.
60. Peet M, Laugharne JD, Mellor J, Ramchand CN. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. Prostaglandins Leukot Essent Fatty Acids 1996;55:71–5.
61. Laugharne JD, Mellor JE, Peet M. Fatty acids and schizophrenia. Lipids 1996;31 Suppl:S163–5.
62. Laugharne JD, Mellor JE, Peet M. Fatty acids and schizophrenia. Lipids 1996;31 Suppl:S163–5.
63. Fenton WS, Dickerson F, Boronow J, et al. A placebo-controlled trial of omega-3 fatty acid (ethyl eicosapentaenoic acid) supplementation for residual symptoms and cognitive impairment in schizophrenia. Am J Psychiatry 2001;158:2071–4.
64. Vaddadi KS, Courtney P, Gilleard CJ, et al. A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. Psychiatry Res 1989;27:313–23.
65. Mellor JE, Laugharne JDE, Peet M. Omega-3 fatty acid supplementation in schizophrenic patients. Hum Psychopharmacol 1996;11:39–46.
66. Shah S, Ramchand CN, Peet M. Eicosapentaenoic acid (EPA) as an adjunct to neuroleptic therapy in the treatment of schizophrenia. Presented at the 9th Schizophrenia Winter Workshop, Davos, Switzerland, February 7–13, 1998.
67. Mellor JE, Peet M. Double-blind, placebo-controlled, trial of omega-3 fatty acids as an adjunct to the treatment of schizophrenia. Presented at the 9th Schizophrenia Winter Workshop, Davos, Switzerland, February 7–13, 1998.
68. Fenton WS, Hibbeln J, Knable M. Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia. Biol Psychiatry 2000;47:8–21 [review].
69. Shamir E, Laudon M, Barak Y, et al. Melatonin improves sleep quality of patients with chronic schizophrenia. J Clin Psychiatry 2000;61:373–7.
70. Manowitz P, Gilmour DG, Racevskis J. Low plasma tryptophan levels in recently hospitalized schizophrenics. Biol Psychiatry 1973;6:109–18.
71. Payne IR, Walsh EM, Whittenburg EJ. Relationship of dietary tryptophan and niacin to tryptophan metabolism in schizophrenics and nonschizophrenics. Am J Clin Nutr 1974;27:565–71.
72. Gilka L. Schizophrenia, a disorder of tryptophan metabolism. Acta Psychiatr Scand Suppl 1975;258:1–83.
73. Bowers MB Jr. Cerebrospinal fluid 5-hydroxyindoles and behavior after L-tryptophan and pyridoxine administration to psychiatric patients. Neuropharmacology 1970;9:599–604.
74. Ko SM, Liu TC. Psychiatric syndromes in pernicious anaemia—a case report. Singapore Med J 1992;33:92–4.
75. Ko SM, Liu TC. Psychiatric syndromes in pernicious anaemia—a case report. Singapore Med J 1992;33:92–4.
76. Majumdar SK, Kakad PP. Serum vitamin B12 status in chronic schizophrenic patients. J Hum Nutr 1981;35:3 [letter].
77. Tsai G, Yang P, Chung LC, et al. D-serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 1998;44:1081–9.
78. Zhang XY, Zhou DF, Zhang PY, et al. A double-blind, placebo-controlled trial of extract of Ginkgo biloba added to haloperidol in treatment-resistant patients with schizophrenia. J Clin Psychiatry 2001;62:878–83.
79. Hoffman RE, Boutros NN, Hu S, et al. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet 2000;355:1073–5.
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2006-09-07
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