Isotretinoin is a modified vitamin A molecule used to treat severe acne vulgaris.
Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.
 May be Beneficial: Side effect reduction/prevention—Taking these supplements may help reduce the likelihood and/or severity of a potential side effect caused by the medication. | Vitamin E* |
 Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. | Vitamin A |
| Depletion or interference | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Vitamin A
Although little is known about how isotretinoin interacts with real vitamin A, the two are structurally similar and have similar toxicities. Therefore, people taking isotretinoin should avoid vitamin A supplements at levels higher than typically found in a multivitamin (10,000 IU per day).
Vitamin E
Preliminary research has found that combined administration of isotretinoin and vitamin E (alpha-tocopherol) substantially reduces the initial toxicity of high-dose isotretinoin without reducing drug efficacy.1 Additional research is needed to further clarify this potentially beneficial interaction.
References
1. Dimery IW, Hong WK, Lee JJ, et al. Phase I trial of alpha-tocopherol effects on 13-cis-retinoic acid toxicity. Ann Oncol 1997;8:85–9.
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2006-09-07
