Combination drug: Estratest/Estratest HS
Methyltestosterone is a hormone used in men to treat testosterone deficiency, and in women to treat breast cancer, as well as breast pain and swelling following pregnancy. It is also combined with estrogen (Estratest®) to treat symptoms associated with menopause.
Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.
 May be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them. | Beta-carotene* Vitamin A* |
 Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. | Zinc |
 Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details. | Androstenedione (Andro)* Dehydroepiandrosterone (DHEA)* |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Vitamin A and Beta-Carotene
A 59-year-old man developed an inability to see well at night following treatment with methyltestosterone.1 Laboratory tests revealed low blood levels of vitamin A and beta-carotene, which may have resulted from taking the drug. More research is needed to determine if vitamin A and beta-carotene supplementation is required for people taking methyltestosterone.
Zinc
Taking methyltestosterone increased the amount of zinc in the blood and hair of boys with short stature or growth retardation.2 It is not known whether this increase would occur in other people or whether zinc supplementation by people taking methyltestosterone would result in zinc toxicity. Until more is known, zinc supplementation should be combined with methyltestosterone therapy only under the supervision of a doctor.
Dehydroepiandrosterone (DHEA)
DHEA supplementation has been shown to increase blood levels of testosterone,3 4 5 as does methyltestosterone. No studies have investigated the possible additive effects of taking DHEA and methyltestosterone, but either increased drug effectiveness or more severe side effects are possible. Until more is known, these agents should be combined only under the supervision of a doctor.
Androstenedione (Andro)
Andro supplementation has been shown to increase blood levels of testosterone in women,6 but not in men.7 No studies have investigated the possible additive effects of taking andro and methyltestosterone, but either increased drug effectiveness or more severe side effects are possible. Until more is known, these agents should be combined only under the supervision of a doctor.
References
1. Nisbett SB, Parker JA, Habal F. Methyltestosterone-induced night blindness. Can J Ophthalmol 1985;20:254–6.
2. Castro-Magana M, Collipp PJ, Chen SY et al. Zinc nutritional status, androgens, and growth retardation. Am J Dis Child 1981;135:322–5.
3. Wolf OT, Neumann O, Hellhammer DH, et al. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab 1997;82:2263–7.
4. Labrie F, Belanger A, Simard J, et al. DHEA and peripheral androgen and estrogen formation: Intracinology. Ann NY Acad Sci 1995;774:16–28.
5. Morales AJ, Nolan JJ, Nelson JC, Yen SSC. Effects of replacement dose of DHEA in men and women of advancing age. J Clin Endorcrionol Metab 1994;78:1360.
6. Mahesh VB, Greenblatt RB. The in vivo conversion of dehydroepiandrosterone and androstenedione to testosterone in the human. Acta Endocrinologica 1962;41:400–6.
7. King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men: a randomized controlled trial. JAMA 1999;281:2020–8.
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2006-09-07
