Triazolam is used for the short-term treatment of insomnia, and is in a family of drugs known as benzodiazepines.
Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.
 May be Beneficial: Supportive interaction—Taking these supplements may support or otherwise help your medication work better. | Melatonin Vinpocetine* |
 Avoid: Adverse interaction—Avoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. | Alcohol Grapefruit juice Pomegranate juice* |
| Depletion or interference | None known |
| Side effect reduction/prevention | None known |
| Reduced drug absorption/bioavailability | None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Melatonin
A preliminary study showed that taking melatonin and triazolam together produces better quality of sleep than occurs when the drug is taken alone. The results also indicated that less triazolam is needed when melatonin and triazolam are taken together, which might reduce side effects such as morning grogginess.1 Additional research is needed to determine whether individuals taking triazolam should also take melatonin.
Vinpocetine
In a preliminary trial, an extract of periwinkle called vinpocetine was shown to produce minor improvements in short-term memory among people taking flunitrazepam, a benzodiazepine.2 Further study is needed to determine if vinpocetine would be a helpful adjunct to use of benzodiazepines, or triazolam specifically.
Interactions with Foods and Other Compounds
Grapefruit juice
Drinking grapefruit juice with triazolam dramatically increases the amount of drug absorbed and the amount of time it stays in the body.3 Though the clinical significance of this interaction is unknown, some people may experience increased side effects, such as morning grogginess, dizziness, and poor coordination. Therefore, people taking triazolam should probably avoid drinking grapefruit juice or eating grapefruit for the duration of therapy.
Pomegranate juice
Pomegranate juice has been shown to inhibit the same enzyme that is inhibited by grapefruit juice.4 5 The degree of inhibition is about the same for each of these juices. Therefore, it would be reasonable to expect that pomegranate juice might interact with triazolam in the same way that grapefruit juice does.
Alcohol
Drinking alcoholic beverages while taking triazolam may enhance side effects such as drowsiness, confusion, and dizziness.6 Consequently, people taking triazolam should avoid drinking alcohol, especially when they must stay alert.
References
1. Ferini-Strambi L, Zucconi M, Biella G, et al. Effect of melatonin on sleep microstructure: preliminary results in healthy subjects. Sleep 1993;16:744–7..
2. Bhatti JZ, Hindmarch I. Vinpocetine effects on cognitive impairments produced by flunitrazepam. Int Clin Psychopharmacol 1987;2:325–31.
3. Sifton DW, ed. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2461–3.
4. Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705–6.
5. Summers KM. Potential drug-food interactions with pomegranate juice. Ann Pharmacother 2006;40:1472–3.
6. Sifton DW, ed. Physicians’ Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 2461–3
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2006-09-07
