Carnosine is a small molecule composed of the amino acids, histidine and alanine. It is found in relatively high concentrations in several body tissues—most notably in skeletal muscle, heart muscle, and brain.1 2
Carnosine has been used in connection with the following conditions (refer to the individual health concern for complete information):
| Science Rating | Health Concerns |
|---|---|
 | Hepatitis C (zinc-L-carnosine) |
 | Peptic ulcers Wound healing |
 Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit. | |
Who is likely to be deficient?
Carnosine deficiency may occur in severe protein deficiency and in certain severe genetic disorders characterized by inborn errors in amino acid metabolism.
How much is usually taken?
For eradication of H. pylori, the amount of the zinc carnosine complex used in research studies was 150 mg twice daily. Due to the lack of human clinical trials, recommended levels for other applications are not known at this time.
Are there any side effects or interactions?
Due to the lack of human studies, side effects and interactions are not known.
References
1. Quinn PJ, Boldyrev AA, Formazuyk VE. Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med 1992;13:379-444.
2. Bonfanti L, Peretto P, De Marchis S, Fasolo A. Carnosine-related dipeptides in the mammalian brain. Prog Neurobiol 1999;59:333-53.
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2006-09-07
