Histidine is called a semi-essential amino acid (protein building block) because adults generally produce adequate amounts but children may not. Histidine is also a precursor of histamine, a compound released by immune system cells during an allergic reaction.
Who is likely to be deficient?
According to limited research, many people with rheumatoid arthritis have low levels of histidine. Taking histidine supplements might improve arthritis symptoms in some people.1
How much is usually taken?
Most people do not need to supplement histidine. Optimal levels for others remain unknown. Human research has used between 1 gram and 8 grams per day.
Are there any side effects or interactions?
No side effects have been reported with histidine. However, people with kidney or liver disease should not consume large amounts of amino acids without consulting a healthcare professional.
References
1. Gerber DA, Gerber MG. Specificity of a low free histidine concentration for rheumatoid arthritis. J Chronic Dis 1977;30:115–27.
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2006-09-07
